By Richard M Fox
Read or Download A monograph of the Ithomiidae (Lepidoptera) Part IV: The tribe Napeogenini Fox, (American Entomological Institute. Memoir) PDF
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Additional resources for A monograph of the Ithomiidae (Lepidoptera) Part IV: The tribe Napeogenini Fox, (American Entomological Institute. Memoir)
However, despite great progress in many laboratories, the molecular bases for both hair cell development and regeneration are still not understood. We propose to test the novel hypothesis that mammalian hair cell regeneration in vivo will be possible if we can induce HCs to re-express the critically important growth factor Bone Morphogenetic Protein 4 (BMP4). In the experiments proposed here, we will make a transgenic "knock-in" mouse, in which BIVIP4 can be expressed in mammalian hair cells under a dual control system.
The binding of IL-4 to its receptor on B cells initiates the dimerization, activation, and nuclear translocation of Stat6 so that it binds to IL-4 response elements in the promoter of IL-4 inducible genes. Germline E transcription follows and permits deletional recombination upstream of the heavy chains that encode for IgE. Knockout models have confirmed in vivo that primary IgE class switching depends upon the activation of the transcription factor Stat6. However, the mechanism for IL-4-mediated secondary or memory IgE remains obscured.
Initial laboratory studies will utilize transfected cell lines and animal models to identify important receptor pathways. Later work will confirm the mechanism of recognition and response to filarial and Wolbachia products in human disease using peripheral blood monocytes from humans infected with Wuchereria bancrofti in Papua New Guinea. Training in laboratory techniques, research methodology and ethics, field based research and clinical tropical medicine will be important components of the project.